In the original timeline, Amy Preston was born in 1990. She had a degree in sociology and a black belt in karate. She often tried to get her half-sister, Lucy Preston, to leave their mother's place of work in search of better opportunities, but Lucy was reluctant to do so.
In the altered timeline, Carolyn and Wallace never meet, causing Amy Preston never to be born. Lucy was distressed over losing Amy, but later decided to continue on the missions, hoping that some day, she'll be able to go on a mission to save Amy. (“Pilot”)
It was stated by Emma Whitmore in 1918 that she made it impossible for Amy to ever be saved, but time will tell.